Open Adventure is a free, open-source old school role playing game. From the description:
Open Adventure is a full-featured tabletop adventure game that offers out-of-box support for medieval fantasy and science-fiction expeditions. In Open Adventure, you play as a heroic or villainous figure free to explore the perilous world created by the all-mighty Game Master. Along your adventure you’ll battle ferocious enemies, solve complex puzzles, navigate labyrinthine mazes–and much more!
Morgalad is a fantasy RPG set in a pre-medieval world. You can download the starter set for free.
For GURPS players, here is an online automated treasure generator.
Cybercity Blues is a free RPG that has a lighter take on the cyberpunk genre. The authors write:
“Cyberblues is a bit like Cyberpunk, only more mellow.”
Cyberblues City is a near-future, action-adventure roleplaying game. Fast-playing and often funny, it offers a lighter take on the cyberpunk genre, both in terms of system and tone. Cyberblues City uses a much modified version of the Fudge roleplaying system designed to make it easy on GMs. And best of all, it is absolutely free.
Mythosa is a free fantasy role playing world for any RPG system. It’s a very complete work, and cold be used right out of the box.